Predicting post-COVID-19 condition in children and young people up to 24 months after a positive SARS-CoV-2 PCR-test: the CLoCk study

Nov 8, 2024 | Government, News, Science

BMC Med. 2024 Nov 7;22(1):520. doi: 10.1186/s12916-024-03708-1.ABSTRACTBACKGROUND: Predicting which children and young people (CYP) are at the highest risk of developing post-COVID-19 condition (PCC) could improve care pathways. We aim to develop and validate...

All-in-one AAV-mediated Nrl gene inactivation rescues retinal degeneration in Pde6a mice

Nov 5, 2024 | Government, News, Science

JCI Insight. 2024 Nov 5:e178159. doi: 10.1172/jci.insight.178159. Online ahead of print.ABSTRACTRetinitis pigmentosa (RP) is a complex group of inherited retinal diseases characterized by progressive death of photoreceptor cells and eventual blindness. Pde6a, which...

A dataset of color fundus images for the detection and classification of eye diseases

Nov 4, 2024 | Government, News, Science

Data Brief. 2024 Oct 4;57:110979. doi: 10.1016/j.dib.2024.110979. eCollection 2024 Dec.ABSTRACTThe retina is a critical component of the eye responsible for capturing visual information, making the importance of retinal health for clear vision. Various eye diseases,...

Lipopeptide-mediated Cas9 RNP delivery: A promising broad therapeutic strategy for safely removing deep-intronic variants in ABCA4

Nov 4, 2024 | Government, News, Science

Mol Ther Nucleic Acids. 2024 Sep 26;35(4):102345. doi: 10.1016/j.omtn.2024.102345. eCollection 2024 Dec 10.ABSTRACTDeep-intronic (DI) variants represent approximately 10%-12% of disease-causing genetic defects in ABCA4-associated Stargardt disease (STGD1). Although...

Researchers seek new treatment for blinding diseases AMD and Stargardt

Oct 28, 2024 | Featured, Lifestyle, News

Research team has identified advanced preclinical candidates targeting the bisretinoid synthesis pathway, which could help treat macular degeneration and Stargardt disease. Read post   Research team has identified advanced preclinical candidates targeting the...

A comparative study of choroidal structural features in eyes with central macular atrophy related to Stargardt disease and non-exudative age-related macular degeneration

Oct 25, 2024 | Government, News, Science

Indian J Ophthalmol. 2024 Nov 1;72(Suppl 5):S887-S892. doi: 10.4103/IJO.IJO_1005_24. Epub 2024 Oct 25.ABSTRACTPURPOSE: To compare choroidal structural features in eyes with central macular atrophy related to Stargardt disease (STGD) and non-exudative age-related...