Heterozygous germline mutations in MSH3, and probably MLH3, act as classical tumour suppressors, leading to excess somatic deletion mutations, signature ID4 and increased colorectal cancer risk

Sep 11, 2026 | Government, News, Science

Gut. 2026 Sep 11:gutjnl-2026-338390. doi: 10.1136/gutjnl-2026-338390. Online ahead of print.ABSTRACTBACKGROUND: MSH3 and MLH3 are non-canonical DNA mismatch repair genes, involved in repairing insertion-deletion mutations. Colorectal cancer (CRC) and adenomas have...

Retinal and choroidal morphometric analysis in fellow eye of unilateral wet age related macular degeneration using optical coherence tomography angiography

Sep 8, 2026 | Government, News, Science

BMC Ophthalmol. 2026 Sep 5;26(1):548. doi: 10.1186/s12886-026-05302-w.ABSTRACTBACKGROUND: Age-related macular degeneration (AMD) when associated with macular neovascularization can cause severe visual morbidity. This study aims to evaluate the retinal and choroidal...

Safety and Effects of Gildeuretinol Acetate on Retinal Atrophic Lesions in Stargardt Disease: The TEASE-1 Randomized Clinical Trial

Sep 3, 2026 | Government, News, Science

JAMA Ophthalmol. 2026 Sep 3:e263662. doi: 10.1001/jamaophthalmol.2026.3662. Online ahead of print.ABSTRACTIMPORTANCE: Stargardt disease (STGD) is the most common macular dystrophy, resulting in profound loss of vision. There is no approved treatment.OBJECTIVE: To...

Deuterated Vitamin A for Stargardt Disease in TEASE-1 Trial

Sep 3, 2026 | Government, News, Science

JAMA Ophthalmol. 2026 Sep 3. doi: 10.1001/jamaophthalmol.2026.3926. Online ahead of print.NO ABSTRACTPMID:42690644 | DOI:10.1001/jamaophthalmol.2026.3926

USH2A-Associated Retinitis Pigmentosa in Koreans: Molecular Genetics and Clinical Characteristics

Sep 3, 2026 | Government, News, Science

Am J Ophthalmol. 2026 Sep 3:S0002-9394(26)00501-5. doi: 10.1016/j.ajo.2026.08.044. Online ahead of print.ABSTRACTPURPOSE: To describe the molecular genetic spectrum and age-related clinical features of USH2A-associated retinitis pigmentosa in Korean patients.DESIGN:...

Epidemiology of macular dystrophy in Japan (2011-2020): a nationwide population-based study

Sep 3, 2026 | Government, News, Science

Jpn J Ophthalmol. 2026 Sep 3. doi: 10.1007/s10384-026-01410-8. Online ahead of print.ABSTRACTPURPOSE: To describe the characteristics and prevalence of macular dystrophy using a comprehensive national claims database in Japan.STUDY DESIGN: Population-based...