As part of a national effort, the National Federation of the Blind South Dakota works to advance the rights, education, and employment opportunities for blind individuals, offering support and resources to ensure full participation in society.

The South Dakota Lions Eye Bank is dedicated to the recovery, processing, and distribution of eye tissues for corneal transplants, playing a crucial role in restoring sight for individuals with corneal blindness in South Dakota.

The South Dakota Chapter of Volunteer Optometric Services to Humanity (VOSH) is committed to offering eye care services to underserved populations worldwide, including vision screenings, eye health education, and the distribution of eyeglasses, facilitated by South Dakota-based volunteers.