Predicting post-COVID-19 condition in children and young people up to 24 months after a positive SARS-CoV-2 PCR-test: the CLoCk study

Nov 8, 2024 | Government, News, Science

BMC Med. 2024 Nov 7;22(1):520. doi: 10.1186/s12916-024-03708-1.ABSTRACTBACKGROUND: Predicting which children and young people (CYP) are at the highest risk of developing post-COVID-19 condition (PCC) could improve care pathways. We aim to develop and validate...

All-in-one AAV-mediated Nrl gene inactivation rescues retinal degeneration in Pde6a mice

Nov 5, 2024 | Government, News, Science

JCI Insight. 2024 Nov 5:e178159. doi: 10.1172/jci.insight.178159. Online ahead of print.ABSTRACTRetinitis pigmentosa (RP) is a complex group of inherited retinal diseases characterized by progressive death of photoreceptor cells and eventual blindness. Pde6a, which...

Lipopeptide-mediated Cas9 RNP delivery: A promising broad therapeutic strategy for safely removing deep-intronic variants in ABCA4

Nov 4, 2024 | Government, News, Science

Mol Ther Nucleic Acids. 2024 Sep 26;35(4):102345. doi: 10.1016/j.omtn.2024.102345. eCollection 2024 Dec 10.ABSTRACTDeep-intronic (DI) variants represent approximately 10%-12% of disease-causing genetic defects in ABCA4-associated Stargardt disease (STGD1). Although...

A dataset of color fundus images for the detection and classification of eye diseases

Nov 4, 2024 | Government, News, Science

Data Brief. 2024 Oct 4;57:110979. doi: 10.1016/j.dib.2024.110979. eCollection 2024 Dec.ABSTRACTThe retina is a critical component of the eye responsible for capturing visual information, making the importance of retinal health for clear vision. Various eye diseases,...

A comparative study of choroidal structural features in eyes with central macular atrophy related to Stargardt disease and non-exudative age-related macular degeneration

Oct 25, 2024 | Government, News, Science

Indian J Ophthalmol. 2024 Nov 1;72(Suppl 5):S887-S892. doi: 10.4103/IJO.IJO_1005_24. Epub 2024 Oct 25.ABSTRACTPURPOSE: To compare choroidal structural features in eyes with central macular atrophy related to Stargardt disease (STGD) and non-exudative age-related...